AA Resveratrol Blast helps burn fat

11 02 2011

I will sum up this study up to make it easy to understand.  Resveratrol helps in the required steps for your body to burn fat.  XCAP’s product is called AA Resveratrol Blast.

Here is a list of other things that AA Resveratrol Blast has been shown to improve in studies.

Up-regulation of Adiponectin by resveratrol: the essential

roles of the Akt/FOXO1 and AMP-activated protein kinase

signaling pathways and DsbA-L.

J Biol Chem. 2011 Jan 7;286(1):60-6.Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University,

Hunan 410011, China.

OBJECTIVE: The natural polyphenol resveratrol (RSV) displays a wide spectrum of health

beneficial activities, yet the precise mechanisms remain to be fully elucidated. Here we show that

RSV promotes the multimerization and cellular levels of adiponectin in 3T3-L1 adipocytes.

METHODS AND RESULTS: The stimulatory effect of RSV was not affected by knocking out

Sirt1, but was diminished by suppressing the expression levels of DsbA-L, a recently identified

adiponectin-interactive protein that promotes adiponectin multimerization. Suppression of the Akt

signaling pathway resulted in an increase in the expression levels of DsbA-L and adiponectin. On

the other hand, knocking out FOXO1 or suppressing the activity or expression levels of the AMP-

activated protein kinase (AMPK) down-regulated DsbA-L and adiponectin. The stimulatory effect

of RSV on adiponectin and DsbA-L expression was completely diminished in FOXO1-suppressed

and AMPK-inactivated 3T3-L1 adipocytes.

CONCLUSIONS: Taken together, our results demonstrate that RSV promotes adiponectin

multimerization in 3T3-L1 adipocytes via a Sirt1-independent mechanism. In addition, we show

that the stimulatory effect of RSV is regulated by both the Akt/FOXO1 and the AMPK signaling

pathways. Last, we show that DsbA-L plays a critical role in the promoting effect of RSV on

adiponectin multimerization and cellular levels.

Advertisements

Actions

Information

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s




%d bloggers like this: