B12 .. Oral vs Injection ????

6 01 2011

I get a lot of questions about B12 shots.  It is usually something like this, “Doc, should I get shots or is B12 Nitro from XCAP strong enough?”

B12 Nitro is extremely effective.


Here is some info:


A study appeared in Blood (August 15, 1998;92 (4):1191-1198) that looked at 38 patients who were diagnosed with vitamin B12deficiency.

The patients were given either a 1 milligram intramuscular injection of cobalamin (on days 1, 3, 7, 10, 14, 21, 30, 60 and 90) or a two milligram oral dose for four months. After four months of therapy, cobalamin levels where higher , and homocysteine levels and methylmalonic acid levels were lower in the group receiving the oral therapy.

That means that the oral dose was more effective than the shot!


An article that appeared in the Journal of the American Medical Association (January 2, 1991;265(1):94-95 ) reviewed the potential of oral B12 therapy for patients with pernicious anemia. A Swedish study found that patients with pernicious anemia were effectively treated with one milligram of oral B12 per day.


B12 Nitro lozenges contain 2 mg. of vitamin B12 and 800 mcg of folic acid in a tasty lozenge that is well tolerated by both the elderly and small children.


The authors of the JAMA article state that the time has come for the use of oral cobalamin therapy. It is cheaper and less invasive than injections.





2 responses

29 01 2011

thanks for good information in your site.
i just have a question.in this supplement we have 200% rda folic acid.as i read in other sites there is an interaction between these(b12&folic acid) that can couse b12 deficiency.so im confused .
hopefully you help me.
thanks a lot

2 02 2011

This product is meant to be utilized mainly as a vitamin B12 supplement, with added benefits due to the inclusion of both B6 and folic acid. Giving this quantity of B12 (2000 mcg) will serve to increase the B12 status.

B12 and folic acid are both B vitamins, and can be supplemented together, ie. one will not cause a deficiency in the other.

However a deficiency in one can be masked by an optimal level of the other. (as indicated by the study below)

“In conclusion, we undertook this investigation to shed light on long-held but evolving ideas about the effects of folic acid fortification on the elderly. We found a higher prevalence of both anemia and cognitive impairment in association with high serum folate in older Americans with a low vitamin B-12 status,” said the researchers. (M.S. Morris, P.F. Jacques, I.H. Rosenberg and J. Selhub. “Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification” Am J Clin Nutr. January 2007, Volume 85, Number 1, Pages 193-200.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: